Opportunity Information: Apply for PAR 27 075
The National Institutes of Health (NIH) is offering an R01 grant opportunity under the trans-NIH Chemical Countermeasures Research Program (CCRP) titled "CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)" (Funding Opportunity Number PAR-27-075). The central aim is to fund basic research that clarifies how toxic "Chemicals of Concern" (CoC), identified by the U.S. Government as significant public health threats, cause skin injury. The emphasis is on understanding the underlying pathological mechanisms of chemical-induced skin damage, rather than running clinical trials, with the longer-term public health objective of strengthening national readiness for chemical incidents.
This NOFO is designed to generate foundational knowledge that can drive the discovery and early-stage development of broad-spectrum medical countermeasures (MCMs). In practical terms, NIH is looking for studies that explain what happens in skin tissue after exposure to high-consequence toxic chemicals: which cellular pathways are disrupted, how inflammation and tissue injury evolve, what molecular and immunologic events lead to acute and longer-lasting damage, and what biological targets might be promising for treatment development. By prioritizing mechanism-focused work, the program aims to build a scientific base that can support countermeasures useful across multiple chemicals, which is especially important for emergency preparedness where exposure scenarios can be unpredictable and varied.
The opportunity falls under the discretionary grant category and uses the standard NIH R01 research project grant mechanism, with clinical trials explicitly not allowed. It is associated with multiple CFDA numbers (93.279, 93.846, 93.855), reflecting NIH programmatic involvement across relevant institutes or centers that support chemical countermeasure and health research. NIH expects to make about five awards under this announcement, with an award ceiling listed at $300,000, indicating the upper limit of support anticipated per award under the program parameters as presented in the source information.
Eligibility is broad across U.S.-based organization types and includes state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations. The NOFO specifically restricts non-U.S. participation in key ways: non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" are allowed as defined by the NIH Grants Policy Statement, which generally means a U.S. applicant organization may include certain foreign activities or collaborations when they meet NIH policy definitions and are appropriately justified, even though a foreign organization cannot be the applicant.
Key timing details in the provided source indicate an original closing date of 2028-11-05, and the opportunity record was created on 2026-05-04. Applicants should still rely on the full NOFO text for the most precise instructions about application due dates, submission windows, budgets, and review criteria, since NIH funding announcements often have multiple receipt dates or specific submission rules. Overall, the opportunity is best viewed as a targeted basic science initiative meant to deepen understanding of chemical injury to skin and to lay the groundwork for broad, deployable countermeasures that could reduce harm and improve outcomes during chemical disasters and emergency exposures.Apply for PAR 27 075
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279, 93.846, 93.855.
- This funding opportunity was created on 2026-05-04.
- Applicants must submit their applications by 2028-11-05.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The opportunity is titled "CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin (R01 Clinical Trial Not Allowed)" under the trans-NIH Chemical Countermeasures Research Program (CCRP).
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PAR-27-075.
Which NIH grant mechanism is being used?
This announcement uses the standard NIH R01 Research Project Grant mechanism.
Are clinical trials allowed under this opportunity?
No. Clinical trials are explicitly not allowed for this R01 opportunity.
What is the main goal of this CCRP initiative?
The central aim is to support basic research that clarifies how high-consequence toxic "Chemicals of Concern" (CoC) cause skin injury, with a focus on understanding underlying pathological mechanisms rather than testing interventions in clinical trials.
What are "Chemicals of Concern" (CoC) in the context of this program?
CoC are toxic chemicals identified by the U.S. Government as significant public health threats. This initiative targets foundational research on how these chemicals injure skin.
What types of scientific questions is NIH looking for projects to address?
NIH is emphasizing mechanism-focused studies that explain what happens in skin tissue after exposure to high-consequence toxic chemicals, including disrupted cellular pathways, the development of inflammation and tissue injury, molecular and immunologic events that drive acute and longer-lasting damage, and identification of potential biological targets relevant to treatment development.
Is the program focused on developing medical countermeasures (MCMs) directly?
The program is designed to generate foundational knowledge that can drive discovery and early-stage development of broad-spectrum medical countermeasures. The immediate emphasis is on basic understanding of injury mechanisms and identification of promising targets, rather than late-stage product development or clinical testing.
What does "broad-spectrum" mean here?
In this context, "broad-spectrum" refers to countermeasure concepts or targets that could be useful across multiple chemicals, which is especially important for emergency preparedness when exposure scenarios can be unpredictable and varied.
Why is the skin a focus for this chemical countermeasures initiative?
The initiative is specifically targeted at understanding chemical-induced skin damage, including both acute injury and longer-lasting effects, as a basis for improving readiness and response to chemical incidents.
What is the longer-term public health objective of the NOFO?
The longer-term objective is to strengthen national readiness for chemical incidents by building a scientific foundation that can support countermeasures aimed at reducing harm and improving outcomes during chemical disasters and emergency exposures.
How many awards does NIH expect to make under this announcement?
NIH expects to make about five awards under this announcement.
What is the award ceiling listed for this opportunity?
An award ceiling of $300,000 is listed, indicating the upper limit of support anticipated per award under the program parameters as presented in the source information.
What is the assistance listing category for this grant?
The opportunity falls under the discretionary grant category.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.279, 93.846, and 93.855, reflecting NIH programmatic involvement across relevant institutes or centers.
Who is eligible to apply?
Eligibility is broad and includes U.S.-based organizations such as state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations.
Are foreign (non-U.S.) organizations eligible to apply as the applicant?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization.
Can a U.S. organization apply if it has a non-U.S. component doing part of the work?
Non-domestic components of U.S. organizations are not eligible to apply. However, "foreign components" are allowed as defined by the NIH Grants Policy Statement, meaning certain foreign activities or collaborations may be included by a U.S. applicant when they meet NIH policy definitions and are appropriately justified.
What is meant by "foreign components are allowed"?
Based on the provided information, this means a U.S. applicant organization may include certain foreign activities or collaborations (as defined and governed by NIH Grants Policy) even though a foreign organization cannot serve as the applicant and non-domestic organizational components are not eligible to apply.
When was this opportunity record created?
The opportunity record was created on 2026-05-04.
What is the original closing date listed for this opportunity?
The original closing date listed is 2028-11-05.
Does the listing provide all application deadlines and submission details?
No. The provided information notes that applicants should rely on the full NOFO text for the most precise instructions about application due dates, submission windows, budgets, and review criteria, since NIH announcements often have multiple receipt dates or specific submission rules.
What kind of research is emphasized: basic, clinical, or both?
The emphasis is on basic research to clarify mechanisms of chemical-induced skin injury. Clinical trials are not allowed.
What is the practical outcome NIH wants from mechanism-focused studies?
The intended practical outcome is a stronger foundational scientific understanding that supports discovery and early-stage development of countermeasures that could be deployed across multiple chemical threats, improving preparedness and response.
Is this opportunity intended for emergency preparedness and national readiness?
Yes. The stated public health objective is to strengthen national readiness for chemical incidents by improving understanding of how chemical threats damage skin and by enabling broad countermeasure development.
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