Opportunity Information: Apply for RFA TS 25 036
The CDC/ATSDR cooperative agreement opportunity "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" (RFA TS 25 036; CFDA 93.061) funds investigator-initiated research aimed at improving understanding of what contributes to ALS risk. The program is designed to support studies that identify and rigorously evaluate potential ALS risk factors, with an explicit preference for proposals that focus on military service-related factors, contact sports exposure, traumatic brain injury, neuroinflammation, and infectious agents. In other words, CDC/ATSDR is looking for projects that can clarify whether and how these exposures and biological processes are associated with ALS, and that can strengthen the overall evidence base in ways that could inform future prevention efforts, surveillance, and public health decision-making.
A central feature of the announcement is that preferred-topic proposals can be submitted under one of three distinct funding options, depending on how mature the evidence base is and what the study is trying to accomplish. Funding Option A is intended for risk factor investigations where the underlying hypothesis already has a well-substantiated foundation and the next step is a stronger, more rigorous evaluation. This option fits projects that have credible existing data but need better study design, larger or more representative samples, improved exposure assessment, stronger comparison groups, or more robust analytic approaches to address bias, confounding, and causal inference. Funding Option B is aimed at novel or early-stage ideas that may have limited preliminary findings or an incomplete evidence base, and are exploratory and developmental in nature. This option is meant for researchers who are testing emerging hypotheses, piloting new methods, generating foundational data, or evaluating feasibility in ways that could later support larger confirmatory studies. Funding Option C is oriented toward improving understanding of ALS risk in specific communities, with emphasis on measuring and characterizing prevalence and incidence in populations such as racial and ethnic minority groups (including Black or African American persons, Hispanic or Latino persons, and Asian persons) and military veterans. This option highlights the public health need to better describe ALS burden and risk in groups that may be understudied, potentially underdiagnosed, or differently exposed due to occupational, environmental, social, or healthcare access factors.
The funding mechanism is a cooperative agreement, which typically indicates substantial involvement by the federal agency during the project period, such as collaboration on scientific priorities, coordination, data harmonization, or dissemination of findings. The opportunity is categorized as discretionary funding in the health area, with an award ceiling of $500,000 and an expected total of eight awards. The original application closing date listed is 2024-11-04, and the opportunity was created on 2024-08-01.
Eligibility is broad and includes many organization types across the public and nonprofit sectors as well as higher education. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education when applying under those nonprofit categories); and other entities, with the listing indicating an unrestricted applicant pool. Overall, the opportunity is structured to encourage a mix of rigorous confirmatory studies, exploratory investigations, and community-focused epidemiologic work, with particular emphasis on military-related exposures, sports and injury history, inflammatory mechanisms, and infectious contributors that may influence ALS risk.Apply for RFA TS 25 036
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.061.
- This funding opportunity was created on 2024-08-01.
- Applicants must submit their applications by 2024-11-04. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others, Unrestricted.
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