NIDCR Research Grants for Analyses of Existing Genomics Data (R01) (Clinical Trial Not Allowed) | PAR 23 133

Opportunity Information: Apply for PAR 23 133

The National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH), is offering an R01 research grant opportunity called "NIDCR Research Grants for Analyses of Existing Genomics Data (R01) (Clinical Trial Not Allowed)" under funding opportunity number PAR-23-133. This is a discretionary federal grant in the health category (CFDA 93.121) intended to fund investigator-initiated research projects that use modern data science methods to analyze genomics datasets that already exist, with a clear focus on questions tied to human dental, oral, and craniofacial (DOC) diseases and conditions. A key feature of this opportunity is that it is specifically designed around secondary analysis of existing and publicly available genomics data rather than generating new clinical trial evidence, and clinical trials are not permitted under this announcement.

The central goal of the program is to accelerate progress in understanding DOC health and disease by leveraging the large volume of genomics information that has already been produced and shared through public repositories and other accessible resources. Projects are expected to pose strong, DOC-relevant biological or clinical questions and answer them by applying computational, statistical, or other data-driven analytic approaches to existing genomics data. In practice, that means competitive applications will typically emphasize rigorous study design for secondary data use, appropriate and well-justified analytic methods, careful handling of bias and confounding, and meaningful interpretation of findings in the context of dental, oral, or craniofacial conditions. The intent is to support research that extracts new knowledge from data that are already available, potentially improving understanding of disease mechanisms, risk, heterogeneity, or related genomic patterns in DOC conditions without requiring collection of new prospective clinical trial data.

Eligibility is broad and includes many types of U.S.-based organizations as well as certain non-U.S. entities. Eligible applicants listed for this opportunity include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other organizations. The announcement also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This breadth signals that NIDCR is open to funding strong teams across academic, governmental, nonprofit, community, and industry settings, including organizations that serve historically underrepresented populations.

Administratively, the opportunity was created on March 28, 2023, and lists an original closing date of May 7, 2026. While the notice includes a field for an award ceiling, no specific ceiling amount is provided in the source information, and the expected number of awards is not specified. As an R01 mechanism, the program is oriented toward substantial, hypothesis-driven or question-driven projects with clear aims, a well-developed analysis plan, and the expertise needed to carry out sophisticated genomics and data science work. Overall, this funding opportunity is best viewed as support for high-impact secondary analyses of existing genomics resources that can advance knowledge directly relevant to dental, oral, and craniofacial diseases and conditions, while staying explicitly outside the scope of clinical trial activity.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIDCR Research Grants for Analyses of Existing Genomics Data (R01) (Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
• This funding opportunity was created on 2023-03-28.
• Applicants must submit their applications by 2026-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 23 133

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