Opportunity Information: Apply for W81XWH 22 NFRP SIA
The Department of Defense (DoD), through the U.S. Army Medical Research Acquisition Activity (USAMRAA), announced the Neurofibromatosis Research Program (NFRP) Synergistic Idea Award (Funding Opportunity Number W81XWH 22 NFRP SIA) to support innovative neurofibromatosis (NF) research built around true collaboration. The central purpose of this mechanism is to fund new ideas that rely on synergistic approaches, meaning the proposed work should be stronger and more impactful because it is driven by a coordinated team rather than a single laboratory working in isolation. Projects are expected to tackle a clearly defined, central problem or question in NF research, with the team structure and work plan showing how the investigators combined perspectives and expertise to address that problem in a way that would not be achievable otherwise.
A defining feature of this opportunity is that applications must be led by two or three Principal Investigators (PIs). The DoD is explicitly looking for complementary skill sets and perspectives, where each PI contributes distinct strengths that meaningfully shape the scientific direction of the project. The award supports both newly formed collaborations and existing partnerships, but it places emphasis on the synergy itself: the investigators should demonstrate how their integration will produce novel insights, methods, or outcomes for NF. The program also encourages participation from PIs outside the traditional NF research community, signaling an interest in cross-disciplinary approaches, such as bringing in expertise from adjacent disease areas, engineering, computational sciences, imaging, drug discovery, or other relevant fields that could accelerate progress in NF.
While the award focuses on new ideas, it is not intended to fund purely speculative concepts without support. Applications are required to include preliminary and/or published data that are relevant to NF and directly tied to the proposed project. In practical terms, this means teams should be prepared to show some evidence that their hypothesis, approach, model system, platform, or underlying observations have a credible connection to NF biology, NF-associated tumors, clinical challenges, or other NF-relevant outcomes, and that the proposed collaborative work is grounded enough to be feasible within the award period.
Administratively, this opportunity was issued as a discretionary funding program within the Science and Technology and other Research and Development activity category, and it lists funding instruments as a Cooperative Agreement and/or Grant. The CFDA number is 12.420, and eligibility is described as unrestricted, meaning it is broadly open to many types of applicant organizations, subject to any additional constraints that might be described in the full announcement. The opportunity was created on April 11, 2022, with an original closing date of July 21, 2022. The posting indicates an expected number of awards of 1. The award ceiling is listed as 0, which typically implies the maximum funding level is either not specified in the summary record or is defined elsewhere in the full funding announcement rather than in this brief listing.
Overall, the NFRP Synergistic Idea Award is best understood as a team-science mechanism aimed at pushing NF research forward by deliberately pairing or grouping investigators whose combined expertise can unlock a higher-impact, more creative solution to a focused NF problem, backed by NF-relevant data and a clearly articulated plan for integrated collaboration.Apply for W81XWH 22 NFRP SIA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Neurofibromatosis, Synergistic Idea Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Apr 11, 2022.
- Applicants must submit their applications by Jul 21, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQ)
What is the name of this grant opportunity?
The opportunity is the Neurofibromatosis Research Program (NFRP) Synergistic Idea Award (SIA).
Who is offering this funding opportunity?
The Department of Defense (DoD), through the U.S. Army Medical Research Acquisition Activity (USAMRAA), announced this funding opportunity.
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is W81XWH 22 NFRP SIA.
What is the main purpose of the NFRP Synergistic Idea Award?
The central purpose is to support innovative neurofibromatosis (NF) research that is built around true collaboration. The program is designed to fund new ideas that become stronger and more impactful specifically because they are driven by a coordinated team rather than a single lab working in isolation.
What does "synergistic" mean in the context of this award?
In this program, "synergistic" means the proposed work should be better, more impactful, or more innovative because of the way the team integrates complementary expertise. The application should show that the outcomes would not be achievable without the coordinated collaboration among the investigators.
What kind of research problem should a project address?
Projects are expected to tackle a clearly defined, central problem or question in NF research. The team structure and work plan should demonstrate how combined perspectives and expertise will address that central problem.
How many Principal Investigators (PIs) are required?
Applications must be led by two or three Principal Investigators (PIs). This is described as a defining feature of the opportunity.
Can a single PI submit an application?
No. Based on the opportunity description provided, applications must be led by two or three PIs.
What does the DoD expect from the multi-PI team?
The DoD is explicitly looking for complementary skill sets and perspectives, where each PI contributes distinct strengths that meaningfully shape the scientific direction of the project. The application should clearly show how the investigators integrate their expertise to produce novel insights, methods, or outcomes for NF.
Are new collaborations allowed, or do teams need to have an established partnership?
Both newly formed collaborations and existing partnerships are supported. The emphasis is on demonstrating real synergy and integration, regardless of how long the team has been working together.
Does this program encourage cross-disciplinary teams?
Yes. The program encourages participation from PIs outside the traditional NF research community. It signals interest in cross-disciplinary approaches that could accelerate progress in NF.
What are examples of "outside the traditional NF research community" expertise areas?
The description gives examples such as adjacent disease areas, engineering, computational sciences, imaging, drug discovery, and other relevant fields that could accelerate NF research progress.
Is this award meant for completely speculative ideas?
No. While the award focuses on new ideas, it is not intended to fund purely speculative concepts without support.
Are preliminary data required?
Yes. Applications are required to include preliminary and/or published data that are relevant to NF and directly tied to the proposed project.
What does it mean for data to be "relevant to NF and directly tied to the proposed project"?
Teams should show evidence that their hypothesis, approach, model system, platform, or underlying observations have a credible connection to NF biology, NF-associated tumors, clinical challenges, or other NF-relevant outcomes. The goal is to demonstrate that the collaborative work is feasible within the award period.
What types of funding instruments are listed for this opportunity?
The posting lists the funding instruments as a Cooperative Agreement and/or Grant.
How is this opportunity categorized administratively?
It was issued as a discretionary funding program within the Science and Technology and other Research and Development activity category.
What is the CFDA number for this opportunity?
The CFDA number listed is 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is broadly open to many types of applicant organizations, subject to any additional constraints that may be described in the full announcement.
What does "unrestricted eligibility" mean here?
Based on the provided summary, it indicates broad eligibility across applicant organization types, although specific requirements or limitations may exist in the full funding announcement.
When was the opportunity created?
The opportunity was created on April 11, 2022.
What was the original closing date?
The original closing date listed is July 21, 2022.
How many awards were expected?
The posting indicates an expected number of awards of 1.
What is the award ceiling (maximum funding)?
The award ceiling is listed as 0 in the summary record. This typically implies that the maximum funding level is not specified in the brief listing and may be defined elsewhere in the full funding announcement.
Where can applicants find the actual maximum funding level if the ceiling is listed as 0?
The summary suggests the maximum funding level may be specified in the full funding announcement rather than in the brief listing.
What makes a strong application for this Synergistic Idea Award, based on the description?
A strong application would (1) focus on a clearly defined central NF problem, (2) be led by two or three PIs with complementary, distinct expertise, (3) demonstrate an integrated collaborative plan where synergy is essential to success, and (4) include preliminary and/or published NF-relevant data directly supporting the proposed approach and feasibility.
Is the award intended to fund general NF research, or specifically team-science projects?
Based on the description, it is specifically a team-science mechanism intended to push NF research forward by pairing or grouping investigators whose combined expertise enables a higher-impact solution to a focused NF problem.
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