Opportunity Information: Apply for RFA DA 23 057
The HEAL Initiative: HEAL Data2Action (D2A) Innovation and Acceleration Projects funding opportunity (RFA-DA-23-057) is an NIH grant program led by the National Institute on Drug Abuse (NIDA) under the broader NIH HEAL Initiative. Its core purpose is to move beyond generating new datasets and instead focus on synthesizing, linking, and using existing data in practical, real-world ways to improve how communities and systems prevent and respond to opioid use disorder (OUD), overdose, and pain-related service needs. The emphasis is on turning data into actionable decision support so that organizations can better predict risk, identify gaps, and make faster, proactive adjustments in policies, clinical workflows, and service delivery.
This opportunity sits inside a larger, coordinated HEAL D2A Program that is being built through multiple related announcements. Alongside these Innovation Projects, NIH is also supporting a Data Infrastructure Support Center, a Research Adoption Support Center, and an Economics and Modeling Resource Center. The intent is for individual local projects to benefit from shared program-wide resources, common approaches, and coordinated learning, rather than operating as isolated pilots. Applicants are expected to understand how their proposed work fits into this broader ecosystem, because the program is designed to accelerate uptake of evidence-based practices across different settings and to improve measurement and accountability using data.
The Innovation Projects themselves are structured as phased awards using the R61/R33 mechanism, with clinical trials allowed but not required (clinical trial optional). The phased structure is meant to support a development-to-implementation pathway. In practice, that typically means an earlier phase focused on getting the data, partnerships, governance, and workflows in place (for example, building or strengthening cross-system data sharing, validating indicators, and designing a responsive operational model), followed by a later phase focused on scaling, operationalizing, and demonstrating real-world impact (for example, embedding dashboards, triggers, referral pathways, or targeted outreach systems into routine operations and showing measurable improvements). The projects are explicitly described as local efforts, which can be housed within a single system (such as a health system, behavioral health network, Medicaid program, or public health department) or built through cross-sector partnerships (such as collaborations among healthcare, EMS, criminal legal systems, social services, housing, community-based organizations, and other community stakeholders).
Programmatically, these projects are expected to address gaps in delivery of evidence-based practices across the four pillars of the HHS Overdose Prevention Strategy: primary prevention, harm reduction, treatment of opioid use disorder, and recovery support. That framing signals that proposals should not be limited to treatment access alone; they can also focus on upstream prevention (for example, safer prescribing supports or early identification of risk), harm reduction service linkage (for example, naloxone distribution targeting or rapid outreach after nonfatal overdose), improving initiation and retention in medications for OUD, and strengthening recovery supports that help people maintain stability (for example, connections to recovery services, housing supports, or wraparound care). Across all pillars, the unifying expectation is that data is used to guide and monitor improvements, meaning projects should describe how data will drive concrete actions, how those actions will be implemented in routine practice, and how outcomes will be tracked over time.
Eligible applicants are broad and include many types of U.S.-based entities that can influence service delivery and population outcomes. Eligibility includes state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments); public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations other than small businesses; and small businesses. The announcement also highlights additional eligible applicant types such as faith-based or community-based organizations and minority-serving institutions (including HBCUs, Hispanic-serving institutions, AANAPISISs, Tribally Controlled Colleges and Universities, and Alaska Native and Native Hawaiian-serving institutions), as well as U.S. territories or possessions and regional organizations. Foreign institutions (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; however, foreign components are allowed as defined by NIH policy, which generally means a U.S. applicant may include certain foreign elements when clearly justified and compliant with NIH rules.
From a funding details standpoint, the grant is categorized as a discretionary NIH grant within education and health activity areas, with CFDA numbers listed as 93.213, 93.273, and 93.279. The source information provided lists an award ceiling of $750,000 and shows an original closing date of November 22, 2022 (with a creation date of September 21, 2022). While the summary does not specify the number of expected awards in the provided excerpt, the overall program language indicates multiple Innovation Projects will be supported as part of a larger coordinated portfolio.
Overall, this opportunity is aimed at organizations that can demonstrate they have access to meaningful data sources (or the ability to build access through partnerships), a realistic plan to turn those data into operational tools for decision-making, and the authority or influence to implement changes in real service settings. The strongest conceptual fit is work that uses timely data to anticipate overdose and OUD-related needs, deploy targeted interventions quickly, and continuously measure whether evidence-based practices are actually reaching people in the community, especially in settings where there are persistent gaps in prevention, harm reduction, treatment engagement, and recovery support.Apply for RFA DA 23 057
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: HEAL Data2Action Innovation and Acceleration Projects, Phased Awards (R61/R33, Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.273, 93.279.
- This funding opportunity was created on 2022-09-21.
- Applicants must submit their applications by 2022-11-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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